Other Associated Conditions

Along with arthritis and arthralgia, myocarditis, and deafness, other rare associations with mumps infection include nephritis, hepatitis, thyroiditis, thrombocytopenia, and ocular complications (e. g., iritis, keratitis, and central retinal vein thrombosis).

ARTHRITIS AND ARTHRALGIA

Mumps may be associated with arthritis or arthralgia infrequently in adults and very rarely in children. Migratory polyarthritis is the most common manifestation, but monarticular arthritis and arthralgia have been reported. Both large and small joints may be involved. Symptoms usually appear 10 to 14 days after the onset of parotitis and may last several weeks. Mumps virus has not been isolated from joint fluid, and no evidence of immune complex deposits has been detected, so the cause of the arthritis is uncertain. The process usually resolves spontaneously without any joint damage.

MYOCARDITIS

Electrocardiographic changes occur in up to 15% of patients with mumps, these being depressed ST segments, flattened or inverted T waves, and prolonged PR intervals. Clinical myocarditis is rare; however, deaths have been reported.

DEAFNESS

Sensorineural hearing loss caused by cochlear damage from the mumps virus can occur infrequently, with an incidence of 0.5 to 5 cases per 100,000 cases of mumps. Deafness may have an abrupt or gradual onset, is often unilateral, and may be transient or more commonly permanent. Vertigo is a common accompaniment.

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